The Leading AI Models, Now Live in Sofie

We have integrated all eight leading large language models into Sofie from Google, Anthropic, and OpenAI, to give our users the flexibility to match the right AI capability to the way that they work. While integrating these models we have observed greater understanding, improvement to long-context reasoning, and meaningful gains in speed of interaction from each model. As the frontier of AI continues to evolve, we’re embedding the best and most reliable options into Sofie. Whether you're running a complex tech transfer workflow, drafting batch records, or summarizing a 200-page regulatory submission, there's a model optimized for exactly that task.

Why Model Choice Matters

Not every workflow demands the same approach. A quick equipment comparison doesn't need the same rigor as a multi-document deviation root cause analysis. And when you're working against a filing deadline, speed matters as much as depth. That's why Sofie has a model-agnostic foundation, so that it can flex to fit your needs.

The Current Model Lineup

Here's what's available now:

For Deep Reasoning and Complex Analysis

• Claude Opus 4.5 — For deep reasoning and complex analysis. Use this when you need thorough deviation investigations or comprehensive risk assessments.

• Gemini 3 Pro Preview — For long conversations and deep reasoning. Ideal for extended tech transfer consultations and multi-turn regulatory Q&A.

For Balanced, All-Purpose Work

• Claude 4.5 Sonnet — Balanced and all-purpose. The versatile model that handles everything from batch record drafting to equipment qualification summaries with consistent quality.

• GPT-5 Mini — A balanced generalist that delivers reliable results across a wide range of technical operations tasks.

For Speed and Efficiency

• GPT-5.2 — For fast, adaptive reasoning that adjusts thinking time based on task complexity. This is our recommended default for most workflows.

• Gemini 3 Flash Preview — Fast and efficient. Great for rapid document processing and real-time support.

• Gemini 2.5 Flash — For fast and lightweight tasks. Perfect for quick lookups, simple queries, and high-volume document triage.

• Claude 4.5 Haiku — For fast and lightweight tasks. Ideal for rapid responses without sacrificing quality.

"We built TransferAI to be model-agnostic because we knew the frontier would keep moving—and moving fast. With eight models now available, our clients can match the right reasoning capability to each workflow: Opus for complex deviation analysis, Flash for high-volume triage, Sonnet for everyday drafting. This isn't about chasing the newest model. It's about giving biopharma teams the precision tooling they need to move faster without compromising quality."

Mark Harrell
Co-Founder & CTO

What’s Next

With eight frontier models now at your fingertips, we're moving beyond AI that simply answers questions to AI that orchestrates complex biopharma workflows from start to finish. This new generation doesn't just draft documents—it reasons through tech transfers, navigates regulatory ambiguity, and surfaces risks before they become deviations.

This is the foundation we're building toward: a future where technical operations teams don't just use AI tools—they direct AI agents that handle entire workflows autonomously. Model choice is the first step. What comes next is AI built on your institutional knowledge, executing your most complex processes with your strategic oversight.

We'll continue expanding model options as the frontier advances. Because in biopharma, the right tool at the right moment can make all the difference.

If you want a fresh set of high-impact ideas tailored to your use of Sofie, request a 1:1.